Intermediates for the preparation of pyrimidine compounds
AssigneeBurroughs Wellcome Co.
InventorsJohn W. Mentha, Janice V. Shaffner, Ronald M. Cresswell
Life of this patent
Estimating the term…
Abstract
There is disclosed a method of making compounds represented by the formula ##SPC1## And which are useful as antimalarial agents. The method includes reacting a keto nitrile with a polyhydroxy compound and then reacting the product with guanidine base. In the above X is a halogen atom or a nitro group, Y is a halogen atom or hydrogen and R is hydrogen or alkyl containing 1 to 10 and preferably is lower alkyl containing 1 to 4 carbon atoms.
Claims18
A compound of the formula ##EQU5## where n = 0, 1 or 2, R is alkyl of 1 to 10 carbon atoms or a hydrogen atom, R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom or lower alkyl of 1 to 4 carbon atoms optionally substituted with hydroxy, lower alkoxy or a halogen atom,
- X is a halogen atom or nitro, Y is a halogen atom or a hydrogen atom, or R.sub.1 and R.sub.2 taken together can complete a 5 to 7 member saturated ring when n = 0.
Dependencies are inferred from the claim text.