4-Aminothiazole
AssigneeSmithKline Corporation
InventorsGregory Gallagher, Jr., William D. Kingsbury
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Abstract
4-Aminothiazole is prepared in stable useful form by alkaline hydrolysis of 4-trifluoroacetamidothiazole. Also prepared are 4-sulfathiazole and 2-(4-thaizolyl)-indazole.
Claims10
4-Aminothiazole and its acid addition salts.
4-Trifluoroacetamidothiazole and its acid addition salts.
The method of preparing 4-aminothiazole comprising reacting 4-trifluoroacetamidothiazole with an ammonium or alkali metal hydroxide in an aqueous medium at from about room temperature up to about 40.degree.C. until the hydrolysis reaction is substantially complete.
The method of preparing 4-aminothiazole comprising reacting 2-bromo-4-trifluoroacetamidothiazole under low pressure catalytic hydrogenation conditions in the presence of a noble metal catalyst to give 4-trifluoroacetamidothiazole then reacting said 4-trifluoroacetamidothiazole with sodium or potassium hydroxide in an aqueous medium at from about 30.degree.-35.degree.C. for about 4-8 hours.
Dependencies are inferred from the claim text.