1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
AssigneeAbbott Laboratories
InventorsJames Daniel Ratajczyk, Robert George Stein, Leo Ralph Swett
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Abstract
Novel 1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones. The compounds exhibit central nervous system activity, particularly anti-convulsant and sedative activity, and also exhibit anti-inflammatory activity and gastric antisecretory activity.
Claims8
A compound represented by the structural formula ##SPC4##
- wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, piperidinomethyl, methoxymethyl, N-methyl-piperazinomethyl, carbethoxy, or p-chlorophenoxymethyl;
- and R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or ##SPC5##
- wherein R is a substituent of the class consisting of halo, methyl, tri fluoromethyl and di(C.sub.1 -C.sub.4)alkylamino (C.sub.1 -C.sub.4)alkyloxy.
A compound in accordance with claim 1, 1,3,5-trimethyl-6-(3-trifluoromethylphenyl)-1H-pyrazolo[4,3-d]-pyrimidine- 7(6H)-one.
A compound in accordance with claim 1, 1,3,5-trimethyl-6-(4-bromophenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one.
A compound in accordance with claim 1, 1,3,5-trimethyl-6-(2,3-dimethylphenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)- one.
Dependencies are inferred from the claim text.