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US 3,939,156 AGranted
Cardenolides
AssigneeKnoll A.G. Chemische Fabriken
InventorsHans Peter Albrecht, Gunter Neugebauer
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Abstract
Novel cardenolides having desirable cardiac activity and which are readily reabsorbed internally, a process for their preparation and therapeutic compositions containing said cardenolides are disclosed.
Claims36
Compound of the formula ##SPC3##
- in which R.sub.1 is alkyl of 1 to 4 carbon atoms, vicinal epoxy- or dihydroxyalkyl of 2 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, or phenyl and R.sub.2 is H or OH.
A process for making a compound of the formula ##SPC4##
- wherein R.sub.2 is H or OH and R.sub.3 is alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, or phenyl, which comprises reacting a compound of the formula ##SPC5##
- with an organo-metallic compound of the formula R.sub.3 -- Me or R.sub.3 MgX, wherein Me is lithium, sodium, or potassium and X is chlorine, bromine, or iodine.
Dependencies are inferred from the claim text.