Process and device for blood examination using substances labelled with radioactive nuclides
AssigneeHoechst Aktiengesellschaft
InventorsStratos Paschalis, Rudolf Kern, Karl-Friedrich Muck
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Abstract
A process and device for determining a hormone in a liquid such as blood wherein measured amounts of the liquid to be tested, of a radioactively-labelled hormone, and of a hormone-binding protein or antibody, all present in a measuring vial, are contacted with an adsorbing vial formed from a mixture of a thermoplastic resin and an ion exchange resin for adsorbing unbound hormone, and the residual radioactivity of the liquid mixture is then measured after draining back into said measuring vial.
Claims11
In a process for determining the concentration of a hormone in a measured amount of liquid which comprises adding thereto measured amounts of radioactively-labelled hormone and of a hormone-binding protein or antibody, contacting the liquid mixture with an ion exchange resin for adsorbing unbound hormone, and then determining the residual radioactivity of the liquid mixture, the improvement wherein said liquid mixture is introduced into a measuring vial, the measuring vial is connected to an adsorption vial formed from a mixture of a thermoplastic resin and an ion exchange resin adsorbing said hormone, the connected measuring and adsorption vials are sealed, the liquid mixture is brought into contact with the walls of the adsorption vial for adsorption of unbound hormone, and the liquid mixture is then drained into said measuring vial for determination of residual radioactivity.
A device for determining the hormone content of a liquid by the addition to said liquid of a radioactively-labelled hormone and a hormone-binding protein or antibody and contact of the mixture with an ion exchange resin for adsorbing unbound hormone, said device comprising a first measuring vial for containing said liquid mixture, said measuring vial having an open end, a second adsorption vial open at both ends detachably connected at one end with the open end of said measuring vial and having closure means at the other end thereof, said adsorption vial being formed from a mixture of a thermoplastic resin and an ion exchange resin adsorbing said hormone.
Dependencies are inferred from the claim text.