Method for attenuating bleeding
AssigneeAmerican Home Products Corporation
InventorsDonald P. Strike, Wenling Kao, Richard L. Fenichei
Life of this patent
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Abstract
The topical application of 7-(5.alpha.-hydroxy-2.beta.-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-3.a lpha.-methyl-1.alpha.-cyclopentyl)-cis-5-heptenoic acid, 7-(5.alpha.-hydroxy-2.beta.-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-1.a lpha.-cyclopentyl)-cis-5-heptenoic acid, or 7-(2.beta.-[(3RS)-hydroxy-3-methyl-trans-1-octenyl]-5-oxo-1.alpha.-cyclope ntyl)-cis-5-heptenoic acid to a wound surface can be employed to attenuate bleeding. The compounds are prepared from the prostaglandin PGA.sub.2.
Claims5
A method for the attenuation of bleeding at a wound surface which comprises the topical application to the wound surface of an effective amount of a compound selected from the group consisting of:
- a. 7-(5.alpha.-hydroxy-2.beta.-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-3.a lpha.-methyl-1.alpha.-cyclopentyl)-cis-5-heptenoic acid;
- b. 7-(5.alpha.-hydroxy-2.beta.-[(3RS)-3-hydroxy-3-methyl-trans-1-octenyl]-1.a lpha.-cyclopentyl)-cis-5-heptenoic acid;
- and
- c. 7-(2.beta.-[(3RS)-hydroxy-3-methyl-trans-1-octenyl]-5-oxo-1.alpha.-cyclope ntyl)-cis-5-heptenoic acid.
Dependencies are inferred from the claim text.