Orally active bronchospasmolytic compounds and their preparation
AssigneeAktiebolaget Draco
InventorsKjell Ingvar Leopold Wetterlin, Leif Ake Svensson
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Abstract
Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##EQU1## wherein R.sub.1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R.sub.2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isoproplyamino-ethanol, having the common name isoprenaline.
Claims7
A method of producing bronchial dilation in animals, including humans, in need therof, comprising the administration of a therapeutically effective amount of a compound selected from the group consisting of ethanol amines having the formulas ##EQU19## wherein R.sub.2 is the acyl radical of a 2-5 carbon fatty acid and pharmaceutically acceptable salts thereof.
A composition for producing bronchial dilation comprising a therapeutically effective amount of a compound selected from the group consisting of the ethanol amines having the formulas:
- ##EQU20## wherein R.sub.2 is the acyl radical of a 2-5 carbon fatty acid and pharmaceutically acceptable salts thereof, in combination with a pharmaceutical carrier.
Dependencies are inferred from the claim text.