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US 3,937,832 AGranted
Esters of 2,2-diphenyl-cyclopropane-carboxylic acids as cough suppressants
AssigneeSociete Anonyme dite: Hexachimie
InventorJean-Claude Cognacq
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Abstract
The invention provides novel aminoethyl esters of 2,2-diphenylcyclopropane carboxylic acids which are anti-tussive agents.
Claims14
A cough-suppressing composition comprising (1) an effective, non-toxic amount of an ester of a 2,2-diphenylcyclopropane-carboxylic acid of the formula:
- ##SPC2## in which R is hydrogen, halogen, lower alkyl, or lower alkoxy, n is zero or 1, and R.sub.1 and R.sub.2 taken together form, with the nitrogen to which they are attached, piperidino or lower alkyl-substituted piperidino;
- or a non-toxic acid addition salt of said ester and (2) a pharmaceutically acceptable excipient.
A method of suppressing cough which comprises administering to a subject suffering therefrom an effective, non-toxic amount of an ester of a 2,2-diphenyl-cyclopropanecarboxylic acid of the formula:
- ##SPC3##
- in which R is hydrogen, halogen, lower alkyl, or lower alkoxy, n is zero or 1, and R.sub.1 and R.sub.2 taken together form, with the nitrogen to which they are attached, piperidino or lower alkyl-substituted piperidino;
- or a non-toxic acid addition salt of said ester.
Dependencies are inferred from the claim text.