Topical anti-inflammatory compositions and methods of use

A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC19##

• where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group;
• and Y is selected from the group consisting of ##SPC20##
• where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC21##
• where n is 1-4, A is selected from the group consisting of H and ##SPC22##
• Z is selected from the group consisting of H, --CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.

A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC23##

• where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group;
• R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC24##
• where n is 1-4, A is selected from the group consisting of H and ##SPC25##
• Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.

A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC27##

• where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group;
• and Y is selected from the group consisting of ##SPC28##
• where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC29##
• where n is 1-4, A is selected from the group consisting of H and ##SPC30##
• Z is selected from the group consisting of H, --CH=NOH CONHOH where one and only one Z in each heterocyclic ring is H.

A composition for treating inflammation comprising about 0.5 to about 5% of an active compound having the structural formula ##SPC31##

• where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group;
• R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC32##
• where n is 1-4, A is selected from the group consisting of H and ##SPC33##
• Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.