Loading patent…
AssigneeKyorin Seiyaku Kabushiki Kaisha
InventorsTsutomu Irikura, Kazunari Shirai, Mamoru Tada, Terumi Tamada, Jun Imai
Estimating the term…
A process for preparing a pyrogen-free plasma substitute consisting of treating hydroxyethyl starch having a DS of 0.5 - 0.6 (preferably 0.55) and an intrinsic viscosity of 0.28 - 0.30 with an acid to lower the molecular weight; adjusting it to the desired hydroxyethyl starch having a DS of 0.55 and an intrinsic viscosity of 0.08- 0.14; adding a depyrogen reagent, such as Raney-nickel to it, if necessary, obtaining an isotonic aqueous solution containing 6% of hydroxyethyl starch and other various salts, preferably, adding sodium chloride (0.5%), potassium chloride (0.03%), calcium chloride dihydrate (0.02%), sodium lactate (0.224%), and glucose (1%)(W/V%) to 6% hydroxyethyl starch solution; and then adjusting the pH of the obtained iostonic aqueous solution to 6.2 .+-. 0.5.
A process for preparing a plasma substitute for injection by treating hydroxyethyl starch having a DS of 0.5-0.6 and an intrinsic viscosity of 0.28-0.30 dl/g in water with dilute hydrochloric acid to obtain a hydroxyethyl starch solution having a DS of 0.5-0.6 and an intrinsic viscosity of 0.08-0.14 dl/g, adding physiologically acceptable electrolytes and glucose to the solution and then diluting the solution with sufficient water to give an isotonic plasma substittute having an oncotic pressure and osmotic pressure equal to those of plasma.
An isotonic plasma substitute having an oncotic pressure and osmotic pressure equal to those of plasma, consisting of 6% (w/v) hydroxyethyl starch having a DS of 0.5 - 0.6 and an intrinsic viscosity of 0.08-0.14 dl/g, physiologically acceptable electrolytes, glucose and water.
An isotonic plasma substitute consisting of 6% (w/v) hydroxyethyl starch having a DS of 0.5 - 0.6 and an intrinsic viscosity of 0.08-0.14 dl/g, 0.5% (w/v) sodium chloride, 0.03% (w/v) potassium chloride, 0.02% (w/v) calcium chloride dihydrate, 0.224% (w/v) sodium lactate and 1% (w/v) glucose, and water.
Dependencies are inferred from the claim text.