Insulin composition providing alternatives to immunological resistance

An insulin composition for providing an alternative to an immunological resistance to insulin of different mixed species of insulin which comprises, in an aqueous suspension, a crystallized insulin and an amorphous des-phenyl-alanine.sup.B1 insulin of the same species, having a pH value in the range of from 6.8 to 7.6, containing zinc ions in an amount of up to 340.gamma./100 I.U., wherein the insulin crystals have a uniform size of from 15 to 35 microns;

• wherein the ratio of crystallized insulin to amorphous des-phenyl-alanine.sup.B1 insulin ranges from 60 :
• 40 to 80 :
• 20;
• and wherein the insulin content is from 40 to 80 I.U. per ml.