Method of stabilizing an injectable composition of a cholecystokinin active octapeptide
AssigneeE. R. Squibb & Sons, Inc.
InventorsMiguel Angel Ondetti, Charles Riffkin, Bernard Rubin, Aaron L. Weiss
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Abstract
A stable composition of the sulfated octapeptide, ##EQU1## having cholecystokinin activity, is obtained by lyophilizing an aqueous solution of the octapeptide and NaCl.
Claims1
A method of enhancing the stability of the octapeptide ##EQU8## against degradation during storage, which comprises lyophilizing a solution containing per liter about 2500 mcg of said octapeptide and about 21.43 g of sodium chloride, and a sufficient quantity of water for injection to adjust the volume to about 1 liter, the pH of the solution being adjusted to from 5.50 to 6.50, if necessary, by addition of sodium hydroxide or hydrochloric acid.
Dependencies are inferred from the claim text.