Steroidal[16.alpha.,17-.beta.]naphthalenes
AssigneeE. R. Squibb & Sons, Inc.
InventorsRavi K. Varma, Christopher M. Cimarusti
Life of this patent
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Abstract
Novel steroids having the structure ##SPC1## And the 1,2-dehydro derivatives thereof, wherein R.sub.1 is chlorine, fluorine, or hydroxy and R'.sub.1 is hydrogen or R.sub.1 and R'.sub.1 together are =0; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, methyl, or fluorine; R.sub.4 is hydrogen, hydroxy, ##EQU1## or halogen; R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkylthio, alkoxy, carboalkoxy, formyl, ##EQU2## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen.
Claims17
A steroid having the structure ##SPC8##
- and the 1,2-dehydro derivative thereof, wherein R.sub.1 is chlorine, fluorine or hydroxy and R'.sub.1 is hydrogen or R.sub.1 and R'.sub.1 together are =O;
- R.sub.2 is hydrogen or halogen;
- R.sub.3 is hydrogen, methyl or fluorine;
- R.sub.4 is hydrogen, hydroxy, ##EQU7## or halogen;
- and R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkylthio, alkoxy, carboalkoxy, formyl, ##EQU8## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen.
Dependencies are inferred from the claim text.