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US 3,937,713 AGranted
Process for the preparation of s-triazolo[3,4-b]benzothiazoles
AssigneeEli Lilly and Company
InventorsCharles J. Paget, James H. Wikel
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Abstract
A novel process for the preparation of s-triazolo[3,4-b]benzothiazole compounds comprises reacting a molar equivalent of base in an amide solvent at a temperature from 60.degree.C. to 200.degree.C. with (a) a 1-acyl-4-(o-halophenyl)thiosemicarbazide compound or (b) a 4-(o-halophenyl)-1,2,4-triazole-3-thiol compound and recovering the product. The s-triazolo[3,4-b]benzothiazole compounds are useful for the control of plant pathogens.
Claims8
A process for preparing an s-triazolo(3,4-b)benzothiazole compound of the formula:
- ##SPC10##
- which comprises commingling a molar equivalent of base in a substantially anhydrous amide solvent at a temperature from about 60.degree.C. to about 200.degree.C. with a 4-(o-halophenyl)-1,2,4-triazole-3-thiol compound of the formula:
- ##SPC11##
- and recovering the product;
- wherein, in the foregoing formulas,
- R is hydrogen, C.sub.1 -C.sub.11 alkyl, cyclopropyl or trifluoromethyl;
- R.sub.1 is hydrogen, bromo, chloro or fluoro;
- R.sub.2 and R.sub.3 are independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, bromo, chloro, fluoro or trifluoromethyl with the limitation that at least one of R.sub.2 and R.sub.3 is hydrogen;
- X is bromo, chloro or fluoro;
- subject to the further limitation that when R.sub.1 is halogen, R is other than hydrogen and R.sub.2 is hydrogen.
7 more elements
Dependencies are inferred from the claim text.