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US 3,937,698 AGranted
Tritiated derivatives of cyclic nucleotides monophosphates
AssigneeBecton, Dickinson and Company
InventorsSidney Gutcho, Raul Rapun, Herman Rutner, Andrew Charig
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Abstract
Tritiated succinylated derivatives of cyclic nucleotides, in particular multitritiated succinylated cyclic adenosine monophosphate, useful in the radioimmunoassay of cyclic nucleotides, and maleyl derivatives of cyclic nucleotides useful in the production of the tritiated derivatives.
Claims27
A compound selected from the group consisting of compounds represented by the following structural formula I:
- ##SPC5##
- wherein
- Y is selected from the group consisting of inosyl, adenyl, uradyl, guanyl, thymyl, cytidyl and the tritium substituted derivatives thereof;
- each R.sub.1 is selected from the group consisting of hydrogen, tritium and lower alkyl;
- and
- each R.sub.2 is selected from the group consisting of tritium and hydrogen with at least one R.sub.2 being tritium;
- and compounds having the following structural formula II:
- ##SPC6##
- wherein
- Z is selected from the group consisting of uradyl, guanyl, inosyl, thymyl, adenyl, cytidyl and the chloro-, bromo and iodo- substituted derivatives thereof;
- and
- each R.sub.4 is selected from the group consisting of hydrogen, chloro, iodo, bromo, and lower alkyl.
9 more elements
Dependencies are inferred from the claim text.