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US 3,935,273 AGranted
Naphthyl acetaldehyde derivatives
AssigneeSyntex Corporation
InventorsJohn H. Fried, Ian T. Harrison
Life of this patent
Estimating the term…
Abstract
2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
Claims11
A compound selected from the group of compounds represented by the formula:
- ##SPC4##
- wherein
- R.sup.1 and R.sup.2 are alkoxy having from 1 to 6 carbons, cycloalkoxy having from 3 to 7 carbons, cycloalkylmethoxy having from 4 to 8 carbons, 2-cycloalkylethoxy having 5 to 9 carbons, 3-cycloalkylpropoxy having from 6 to 10 carbons, monocyclic arylmethoxy having from 7 to 13 carbons, 2-phenylethoxy or 3-phenylpropoxy;
- or R.sup.1 and R.sup.2 taken together are oxo;
- one of R.sup.6 and R.sup.7 is hydrogen and the other is hydrogen, methyl, ethyl or difluoromethyl;
- or R.sup.6 and R.sup.7 taken together are methylene, ethylene or halomethylene;
- and
- R.sup.9 is difluoromethoxy, alkoxymethyloxy having up to 7 carbons, difluoromethylthio, alkoxymethylthio having up to 6 carbons, or alkylthiomethylthio having up to 7 carbons.
5 more elements
Dependencies are inferred from the claim text.