PGE.sub.2 -oxa-phenylene compounds

An optically active compound of the formula:

• ##SPC144##
• or a racemic mixture of that compound and the enantiomer thereof, wherein C.sub.j H.sub.2j represents a valence bond or alkylene of one or 2 carbon atoms, with one chain carbon atom between --CH=CH-- and the phenylene ring;
• wherein C.sub.p H.sub.2p represents a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 chain carbon atoms between the ring and --O--;
• wherein C.sub.j H.sub.2j and C.sub.p H.sub.2p together represent zero to 6 carbon atoms, inclusive, with total chain lengths zero to 3 carbon atoms, inclusive;
• wherein G is (1) alkyl of 2 to 10 carbon atoms, inclusive, substituted with zero, one, 2, or 3 fluoro or (2) a monovalent moiety of the formula ##SPC145##
• wherein C.sub.t H.sub.2t represents a valence bond or alkylene of one to 10 carbon atoms, inclusive, substituted with zero, one, or 2 fluoro, with one to 7 carbon atoms, inclusive, between ##EQU92## and the ring, wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR.sub.6, wherein R.sub.6 is hydrogen or alkyl of one to 4 carbon atoms, inclusive, and wherein s is zero, one, 2, or 3, with the proviso that not more than two T's are other than alkyl;
• wherein Q is ##EQU93## wherein R.sub.2 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
• wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, wherein .about. indicates attachment of the side chain to the cyclopentane ring in alpha or beta configuration;
• including the lower alkanoates thereof and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.