6-[.alpha.-(.omega.-QUANIDINOALKANOYLAMIDO)ACYLAMIDO]PENICILLANIC ACIDS

A compound of the formula ##EQU31## and the pharmaceutically acceptable acid addition salts thereof wherein R is selected from the group consisting of hydrogen and acyloxy lower alkyl wherein acyloxy is selected from the group consisting of lower alkanoyloxy, benzoyloxy and substituted benzoyloxy wherein the substituent is selected from the group consisting of chloro, bromo, fluoro, lower alkyl, lower alkoxy and trifluoromethyl;

• R.sub.1 is selected from the group consisting of hydrogen, alkyl of from 1 to 14 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, 1,4-cyclohexadienyl, naphthyl, benzyl, phenethyl, furyl, thienyl, and ##SPC15##
• wherein Y is selected from the group consisting of hydrogen, nitro, di(lower alkyl)amino, lower alkanoylamino, lower alkyl, lower alkoxy, hydroxy, sulfamyl, chloro, bromo, fluoro, iodo, and trifluoromethyl;
• R.sub.2 is selected from the group consisting of hydrogen and lower alkyl;
• R.sub.1 and R.sub.2 when taken together with the carbon atom to which they are attached are cycloalkylidene of 3 to 10 carbon atoms;
• each of R.sub.3 and R.sub.6 is selected from the group consisting of hydrogen, lower alkyl, benzyl, and phenyl;
• R.sub.4 and R.sub.5 when taken together with the quanyl moiety to which they are attached form a 5-membered heterocyclic ring selected from the group consisting of 2-imidazolyl, and 2-(2-imidazolinyl) and
• X is selected from the group consisting of alkylene having from 1 to 7 carbon atoms, phenylene, cycloalkylene having from 3 to 9 carbon atoms, propenylene whose --CH.sub.2 group is bound to the adjacent nitrogen;
• vinylenephenylene, methylene oxyphenylene and phenylenemethylene, each of whose phenylene group is bound to the adjacent nitrogen.