Process for the preparation of granules
AssigneeMeiji Seika Kabushiki Kaisha
InventorsShojiro Ito, Akira Takami, Tokio Takekoshi
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Abstract
Granules are prepared by subjecting a crystalline sugar, a basis, adjuvants and a binder-containing solution to a mixing apparatus, followed by crushing and drying by conventional techniques. The resultant products are characterized by having a uniform granular size, good disintegrating properties, relatively great apparent density and abrasion resistance. The basis comprises at least one member selected from the group of penicillin, tetracycline, movobiocin, kanamycin, paromomycin and midecamycin.
Claims9
Process for the preparation of granular product of uniform particle size, good disintegrating properties, relatively great apparent density and abrasion resistance, which comprises the steps of:
- (a) mixing a crystalline sugar and a finely powdered basis having a particle size of from about 177.mu. to about 500.mu. in a mixing apparatus in the presence of about 15% by weight based on the total combined weight of said sugar and said basis of a solution containing from about 0.1 to 3.0% by weight of binder based on the same total combined weight, said basis comprising at least one member selected from the group consisting of penicillin, tetracycline, novobiocin, kanamycin, paromomycin and midecamycin;
- (b) crushing the resultant wetted mixture of sugar, basis and binder solution in the form of lumps;
- and (c) removing the remaining solvent from the said solution of the binder, and recovering the granular product therefrom.
Dependencies are inferred from the claim text.