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US 3,932,479 AGranted
Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates
AssigneeAmerican Cyanamid Company
InventorsKarel Francis Bernady, Middleton Brawner Floyd, Jr., John Frank Poletto, Robert Eugene Schaub, Martin Joseph Weiss
Life of this patent
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Abstract
This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
Claims9
Compounds of the formula:
- ##EQU22## wherein R' is an alkyl group having from 1 to 10 carbon atoms which may be different when t is greater than one;
- R is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms;
- W is selected from a group consisting of lower alkyl, triphenylmethyl, triphenylmethyl in which one or two of the phenyl rings is substituted with a lower alkoxy group, tetrahydropyranyl, .alpha.-(lower alkoxy) substituted lower alkyl and tri(lower alkyl)silyl;
- s is an integer having the value of one to three, inclusive, and t is an integer having the values of one to three, inclusive, with the proviso that the sum of s and t must be equal to four.
1 more element
Compounds of the formula:
- ##EQU23## wherein R is lower alkyl;
- R.degree. is lower alkyl;
- and R' is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms.
Dependencies are inferred from the claim text.