Microbiological reduction of PGA.sub.2 and 15-epi PGA.sub.2
AssigneeAmerican Home Products Corporation
InventorsGeorge Greenspan, Michael R. G. Leeming
Life of this patent
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Abstract
Reduction of 7(2-[(3R and 3S)-3-hydroxy-1-octenyl]-5-oxo-3-cyclopenten-1-yl)-5-heptenoic acid by microorganisms of the genera Streptomyces, Pseudomonas and Corynebacterium is disclosed. The products 7-(2-[(3R)-3-hydroxy-1-octenyl]-5-oxo-cyclopentyl)-5-heptenoic acid(11-deoxy-15-epi-PGE.sub.2), which is novel, and 7-(2-[(3S)-3-hydroxy-1-octenyl]-5-oxo-3-cyclopentyl)-5-heptenoic acid(11-deoxy-PGE.sub.2), respectively, are useful as intermediates for the synthesis of other physiologically active ingredients.
Claims13
A process for the preparation of 7-[2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentyl]-5-heptenoic acid which comprises subjecting 7-[2-(3-hydroxy-1-octenyl)-5-oxo-cyclopenten-1-yl]-5-heptenoic acid to the fermentative action of an organism selected from the genera:
- a. Streptomyces,
- b. Pseudomonas, and
- c. Corynebacterium;
- and then isolating the prostaglandin product.
Dependencies are inferred from the claim text.