A computer-implemented method of detecting a biological feature in an image of a tissue specimen

Abstract

There is a provided a computer-implemented method of detecting a biological feature in an image of a tissue specimen, the method comprising the steps of: (a) provide an input image of a tissue specimen at a first image size and at a first resolution; (b) downscale the image to a second resolution that is lower than the first resolution; (c) input the downscaled image into a first machine learning algorithm to detect one or more biological feature candidates; (d) crop the input image into one or more sub-images, at least one sub-image having a second image size that is smaller than the first image size and each sub-image containing at least one biological feature candidate; and (e) input the at least one sub-image into a second machine learning algorithm to provide an output prediction of whether the biological feature is present in the at least one sub-image.

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