Combination therapy of polio virus receptor inhibitors and fucose
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorEric K. LE-LAU
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Abstract
Disclosed are methods for detecting and treating cancers and, in particular, metastasis based on the fucosylation of polio virus receptor (PVR). Said methods can comprise the detection of the fucosylation of PVR; wherein an increase or the presence of fucosylated PVR indicates a cancer and/or metastasis. Also disclosed are methods of treating said cancer comprising administering to a subject an agent that inhibits PVR and an agent that increases fucosylation.
Claims16
A method of treating a cancer and/or metastasis in a subject comprising administering to the subject an agent that blocks polio virus receptor (PVR) and an agent that increases fucosylation.
A method of detecting the presence of a brain metastasis or measuring the progression of a brain metastasis in a subject with breast cancer, comprising:
- a) obtaining a tissue sample from a subject, and
- b) measuring the amount of secreted fucosylated PVR in the sample, wherein the presence of or an increase in fucosylated PVR relative to a control indicates the presence of a brain metastasis.
A method of treating a cancer and/or metastasis in a subject, comprising:
- a) obtaining a tissue sample from a subject;
- b) measuring the amount of secreted fucosylated PVR in the sample, wherein the presence of or an increase in fucosylated PVR relative to a control indicates the presence of a brain metastasis;
- and
- c) administering to the subject an agent that blocks polio virus receptor and an agent that increases fucosylation when the presence of or an increase in fucosylated PVR is detected.
Dependencies are inferred from the claim text.