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US 2026/0309712 A1Published application
Compositions and methods for detection of aberrant cdk5 expression
AssigneesArizona Board of Regents on Behalf of the University of Arizona, The UAB Research Foundation
InventorsJames BIBB, Priyanka GUPTA, Angela CARTER
Life of this patent
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Abstract
Improved antibodies for detection of phosphorylated RBL1, H1.5, LARP6, SUV39H1, and FAM53C have been developed. Assays using them to detect the biomarkers: P-T143 FAM53C, P-T202 LARP6, P-S988 RBL1, P-S17 H1.5, and P-S391 SU-V39H1, and diagnostic and prognostic applications stemming therefrom are also provided.
Claims24
An antibody or other molecule comprising an antigen binding domain of an antibody that immunospecifically binds to the epitope:
- (i)
- (SEQ ID NO:
- 1)
- CSIYI-pS-PHKN;
- (ii)
- (SEQ ID NO:
- 14)
- CAPVEK-pS-PAK;
- (iii)
- (SEQ ID NO:
- 27)
- CALA-pT-PQKNGRV;
- (iv)
- (SEQ ID NO:
- 40)
- CLAGLPG-pS-PKKRVR;
- or
- (v)
- (SEQ ID NO:
- 53)
- CAPSKLW-pT-PIKH.
18 more elements
-14. (canceled)
(canceled)
-28. (canceled)
-35. (canceled)
Dependencies are inferred from the claim text.