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US 2026/0309694 A1Published application
Method
AssigneeOxford Nanopore Technologies PLC
InventorsLakmal Nishantha Jayasinghe, John Joseph Kilgour, Neil Roger Wood
Life of this patent
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Abstract
The invention relates to a novel method of producing hetero-oligomeric pores. The invention also relates to hetero-oligomeric pores produced using the method and polynucleotide characterisation using the hetero-oligomeric pores.
Claims13
1-44. (canceled)
A hetero-oligomeric transmembrane pore comprising a first monomer and a second monomer at a specific stoichiometric ratio in the range of 1:13 to 13:1, wherein the specific stoichiometric ratio is not 1:1, wherein the first monomer is different from the second monomer, and wherein:
- (i) the first monomer comprises SEQ ID NO:
- 2 while the second monomer comprises a variant of SEQ ID NO:
- 2, or the first monomer comprises a variant of SEQ ID NO:
- 2 while the second monomer comprises SEQ ID NO:
- 2, or the first monomer comprises a first variant of SEQ ID NO:
- 2 while the second monomer comprises a second variant of SEQ ID NO:
- 2 that is different from the first variant;
- or
- (ii) the first monomer comprises SEQ ID NO:
- 32 while the second monomer comprises a variant of SEQ ID NO:
- 32, or the first monomer comprises a variant of SEQ ID NO:
- 32 while the second monomer comprises SEQ ID NO:
- 32, or the first monomer comprises a first variant of SEQ ID NO:
- 32 while the second monomer comprises a second variant of SEQ ID NO:
- 32 that is different from the first variant.
12 more elements
Dependencies are inferred from the claim text.