Microrna as a diagnostic tool and for developing advanced therapies of amyotrophic lateral sclerosis (als) with bulbar onset
AssigneesFondazione I.R.C.C.S. Istituto Neurologico "Carlo Besta", Consiglio Nazionale Delle Ricerche
InventorsStefania MARCUZZO, Erika SALVI, Eleonora DALLA BELLA, Davide PERICO, Antonella DE PALMA, Pierluigi MAURI, Giuseppe LAURIA PINTER
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Abstract
The present patent application describes microRNAs for the diagnosis and development of advanced therapies for amyotrophic lateral sclerosis (ALS) with bulbar onset.
Claims11
Use of specific microRNAs in the diagnosis of amyotrophic lateral sclerosis (ALS) with bulbar onset, where said specific microRNAs are represented by:
- miR-150-5p
- UCUCCCAACCCUUGUACCAGUG
- miR-483-5p
- AAGACGGGAGGAAAGAAGGGAG.
The use of specific microRNAs in the diagnosis of amyotrophic lateral sclerosis (ALS) with bulbar onset, wherein said expression is measured in an isolated serum sample of a patient suspected of having said disease.
A diagnostic method for the diagnosis of amyotrophic lateral sclerosis (ALS) with bulbar onset in a patient suspected of having this specific form of disease comprising the step of determining the expression of microRNAs represented by:
- miR-150-5p
- UCUCCCAACCCUUGUACCAGUG
- miR-483-5p
- AAGACGGGAGGAAAGAAGGGAG
- in an isolated biological sample of a patient suspected of having said disease.
A microRNA for medical use in the treatment of patients affected by amyotrophic lateral sclerosis (ALS) with bulbar onset with guanabenz or with drugs acting on the endoplasmic reticulum stress and on the cellular response defined as unfolded protein response, wherein said microRNA is represented by:
- miR-106b-5p
- UAAAGUGCUGACAGUGCAGAU.
The microRNA for medical use in the treatment of patients affected by amyotrophic lateral sclerosis (ALS) with bulbar onset according to the claim &, wherein said expression value is determined in an isolated serum sample of said patient.
Use of microRNAs for developing a therapeutic approach for amyotrophic lateral sclerosis (ALS) with bulbar onset, wherein said microRNAs are represented by:
- miR-150-5p
- UCUCCCAACCCUUGUACCAGUG
- miR-483-5p
- AAGACGGGAGGAAAGAAGGGAG.
Dependencies are inferred from the claim text.