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US 2026/0308678 A1Published application
Method for analyzing oligonucleotide
AssigneeShimadzu Corporation
InventorTakashi NISHIKAZE
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Abstract
The present disclosure provides a method for analyzing an oligonucleotide, the method including: an application step of applying a sample containing the oligonucleotide and a matrix to a plate; an acquisition step of performing mass spectrometry by irradiating the sample applied to the plate with a laser beam in a MALDI mass spectrometer to acquire a mass spectrum; and a determination step of, when a peak other than a peak derived from the oligonucleotide is observed in the acquired mass spectrum, determining that the sample may contain an impurity.
Claims9
A method for analyzing an oligonucleotide, the method comprising:
- an application step of applying a sample containing the oligonucleotide and a matrix to a plate;
- an acquisition step of performing mass spectrometry by irradiating the sample applied to the plate with a laser beam in a MALDI mass spectrometer to acquire a mass spectrum;
- and
- a determination step of, when a peak other than a peak derived from the oligonucleotide is observed in the acquired mass spectrum, determining that the sample may contain an impurity,
- wherein
- the intensity of the laser beam is an intensity that can suppress in-source decay of the oligonucleotide, and
- the matrix includes an acetophenone-based compound.
4 more elements
Dependencies are inferred from the claim text.