Nucleic Acid Scaffolds and Related Devices and Methods

Abstract

Provided are nucleic acid scaffolds. In some embodiments, the nucleic acid scaffolds comprise a structure having a fixed or variable resistance operably coupled to site-specifically metalized nucleic acid regions within the nucleic acid scaffold. The structure having a fixed or variable resistance comprises an opening formed by one or more non-metalized nucleic acid regions of the nucleic acid scaffold, and when in use, conductance between two or more of the site-specifically metalized nucleic acid regions is conditioned upon a state of the structure having fixed or variable resistance. In some instances, the state of the structure is the presence or absence of an analyte within the opening, e.g., the presence or absence of a polymer (e.g., a nucleic acid or protein) translocating through the opening. Also provided are devices and methods that employ the nucleic acid scaffolds of the present disclosure, e.g., for detection and/or analysis of analytes of interest.

Dependencies are inferred from the claim text.