Compositions and Methods for Increasing AAV Productivity
AssigneeOxford Biomedica (US) LLC
InventorsLaura van Lieshout, Diane Golebiowski
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Abstract
Provided are vectors and vector systems for the production of recombinant adeno-associated viral vectors, as well as methods of using the vectors and vector systems to optimize productivity.
Claims21
A vector comprising nucleic acid E4, nucleic acid E2a, and virus-associated (VA) RNA of an adenovirus genome, wherein nucleic acid E4 comprises a deletion of open reading frames 1-3.
A vector system comprising a first vector and a second vector, wherein the first vector comprises at least a portion of nucleic acid E4, at least a portion of nucleic acid E2a, and virus-associated (VA) RNA of an adenovirus genome, wherein the at least a portion of nucleic acid E4 comprises a deletion configured to increase production of an AAV product comprising AAV capsids as compared to production using a vector lacking the nucleic acid E4 deletion.
Dependencies are inferred from the claim text.