Lentiviral delivery of anti-cd20 chimeric antigen receptors

A lentiviral particle, comprising:

• a polynucleotide encoding a chimeric antigen receptor (CAR) that specifically binds cluster of differentiation-20 (CD20),
• wherein the CAR comprises a VL or VH sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% identical to SEQ ID NO:
• 176 or 179;
• and
• wherein the lentiviral particle comprises any of the following:
• a heterologous viral glycoprotein (G protein),
• a surface displayed polypeptide selected from:
• an anti-CD3 antibody or antigen-binding fragment, a CD28 ligand, or a 4-1BB ligand, or
• a fusion molecule comprising:
• a CD58 extracellular domain, or a functional fragment thereof, a CD80 or CD86 extracellular domain, or a functional fragment thereof, and an anti-CD3 antibody or antigen-binding fragment thereof.