Retroviral vectors
AssigneeUCL Business PLC
InventorsJohn COUNSELL, Antonio GRECO, Zeinab ASGARIAN, Ala'a SIAM, Luke TAPPOUNI
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Abstract
This invention relates to a novel retroviral vector comprising a 5′ long terminal repeat (LTR), a primer binding site, a heterologous intron, a transgene insertion site and a 3′ LTR, wherein the heterologous intron is located immediately downstream of the 5′ LTR. Such vectors have high titre production rates and are particularly suited for gene therapy.
Claims25
A retroviral vector comprising a 5′ long terminal repeat (LTR), a primer binding site, a heterologous intron, a transgene insertion site, and a 3′ LTR, wherein the heterologous intron is located immediately downstream of the 5′ LTR.
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Dependencies are inferred from the claim text.