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US 2026/0308599 A1Published application
Materials and methods for aptamer selection
AssigneeThe Penn State Research Foundation
InventorsYong WANG, Naveen SINGH
Life of this patent
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Abstract
Described are methods for identifying or producing an aptamer to a target. The target can be conjugated to a microporous hydrogel. Described are also aptamer-target complexes including an aptamer and a target, where the target is conjugated to a porous hydrogel, and the aptamer selectively associates with the target.
Claims22
An aptamer-target complex comprising:
- an aptamer;
- and
- a target,
- wherein the target is conjugated to a porous hydrogel, and
- wherein the aptamer selectively associates with the target.
2 more elements
A method for identifying or producing an aptamer to a target, the method comprising:
- contacting a candidate mixture of nucleic acids with the target, wherein nucleic acids having affinity to the target bind the target and form nucleic acid-target complexes;
- partitioning nucleic acid-target complexes from free nucleic acids in the candidate mixture;
- and
- identifying nucleic acids that bind to the target, thereby identifying or producing an aptamer to a target;
- wherein the target is conjugated to a porous hydrogel.
2 more elements
-30. (canceled)
-34. (canceled)
Dependencies are inferred from the claim text.