Biological libraries and methods of preparing and using same
OwnerRita E. Serda, Jimin GUOinventors
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Abstract
A biological library that includes a plurality of cryo-silicified cells, a plurality of dehydrated cryo-silicified cells, or both, where the cryo-silicified cells and/or the dehydrated cryo-silicified cells contain accessible biological information. In some embodiments, the biological information includes genetic information, proteomic information, or transcriptomic information. Members of the library may be analyzed to identify changes in the biological information associated with a medical condition or response to treatment. When the library includes B lymphocytes, cellular material from the B lymphocytes may be used to produce an antibody.
Claims20
A library composition comprising:
- a plurality of cryo-silicified cells, a plurality of dehydrated cryo-silicified cells, or both, wherein at least a portion of the cryo-silicified cells, the dehydrated cryo-silicified cells, or both comprises accessible biological information.
A method comprising:
- obtaining a sample comprising a cell;
- cryo-silicifying the sample to create a cryo-silicified sample.
A method comprising:
- obtaining a first cell from a subject;
- cryo-silicifying the first cell create a cryo-silicified cell;
- storing the cryo-silicified cell;
- isolating a first cellular material from the cryo-silicified cell;
- obtaining a second cell;
- isolating a second cellular material from the second cell;
- and
- analyzing the first cellular material and the second cellular material for a difference between the first cellular material and the second cellular material.
Dependencies are inferred from the claim text.