Anti-cancer treatments and methods of use thereof
OwnerAndrew M. INTLEKOFER, Shengqi HOUinventors
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Abstract
This invention is directed to anti-cancer treatments and methods of use thereof.
Claims91
A method for treating a cancer in a subject, the method comprising hyperactivating an oncogenic activity of an enzyme in cancer cells.
46A. The method of claim 43, wherein the molecule interacts with one or more homologous amino acid residues in IDH1.
46B. The method of claim 46A, wherein the one or more homologous amino acids in IDH1 are selected from the group consisting of K203, G204, W205, P206, Y208, K243, W245, R249, M254, Q257, S261, E262 and G264.
A method of treating a cancer containing a mutant isocitrate dehydrogenase (mutIDH), the method comprising administering to a subject a composition that increases activity of the mutIDH in cancer cells.
A method for identifying a compound that interacts with cancer cells having a mutant isocitrate dehydrogenase (mutIDH), the method comprising screening for compounds that activate the mutIDH in a cell, wherein the mutIDH uses NADH to reduce α-ketoglutarate to 2-hydroxyglutarate.
A method for treating a cancer in a subject, the method comprising:
- administering to the subject a vector comprising a gene encoding a hyperactivated mutant isocitrate dehydrogenase (mutIDH);
- and
- expressing the mutIDH in cancer cells.
A method for treating a cancer in a subject, the method comprising:
- introducing a modification to an endogenous mutIDH gene to hyperactivate the gene in a cell of the cancer in the subject.
Dependencies are inferred from the claim text.