Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
AssigneeFred Hutchinson Cancer Center
InventorMatthias Stephan
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Abstract
The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.
Claims18
A method of treating a tumor in a subject, the method comprising implanting a composition proximal to a tumor cell in the subject, wherein the composition comprises (i) a porous scaffold and (ii) T lymphocytes and/or natural killer cells disposed within the porous scaffold.
Dependencies are inferred from the claim text.