Metabolic switches for anti-tumor immunity
AssigneeCold Spring Harbor Laboratory
InventorsSemir Beyaz, Ilgin Ergin, Timothy Maher, Paul Bunk, Vyom Shah, Charlie Chung
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Abstract
Provided herein are fusion proteins comprising a peroxisome proliferator-activated receptor delta (PPAR-5) sequence linked to an activation domain sequence for increasing immune cell activity against cancer cells and also provided herein are CPT1A proteins for increasing immune cell activity against cancer cells.
Claims101
A method of engineering an immune cell comprising introducing into an immune cell a fusion protein that comprises or consists of:
- (a) a peroxisome proliferator-activated receptor delta (PPAR-δ) sequence linked to (b) an activation domain sequence.
A method of increasing T cell-mediated cytotoxicity comprising introducing into a T cell a fusion protein that comprises:
- (a) a peroxisome proliferator-activated receptor delta (PPAR-δ) linked to (b) an activation domain sequence.
A method of treating a subject with cancer comprising administering to the subject an immune cell comprising a fusion protein that comprises:
- (a) a peroxisome proliferator-activated receptor delta (PPAR-δ) linked to (b) an activation domain sequence.
A method of engineering an immune cell comprising introducing into an immune cell a CPT1A protein.
A method of treating a subject with cancer comprising administering to the subject an immune cell comprising a CPT1A protein.
A method of increasing T cell-mediated cytotoxicity comprising introducing into a T-cell a CPT1A protein.
A T-cell comprising:
- (a) a chimeric antigen receptor and (b) a fusion protein that comprises or consists of:
- (i) a peroxisome proliferator-activated receptor delta (PPAR-δ) linked to (ii) an activation domain sequence.
A T-cell comprising:
- (a) a chimeric antigen receptor and (b) a fusion protein that comprises or consists of:
- (i) a peroxisome proliferator-activated receptor delta (PPAR-δ) linked to (ii) an activation domain sequence.
A T-cell comprising:
- (a) a chimeric antigen receptor and (b) an engineered polynucleotide encoding (i) a peroxisome proliferator-activated receptor delta (PPAR-δ) linked to (ii) an activation domain sequence or (c) a chimeric antigen receptor and (d) an engineered polynucleotide encoding a CPT1A.
Dependencies are inferred from the claim text.