Microphysiological system devices with self-contained photonic integrated circuit sensors
AssigneeUniversity of Rochester
InventorsJoseph BUCUKOVSKI, Michael BRYAN, Daniel J. STEINER, John S. COGNETTI, Katherine A. DANIEL, Raquel E. AJALIK, Hani A. AWAD, James L. McGRATH, Benjamin L MILLER
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Abstract
The disclosure provides microphysiological systems (“MPS”) that have self-contained, on-board photonic integrated circuit sensors. The self-contained, on-board photonic integrated circuit sensors can be coupled from the back side of the sensors, allowing the MPS to be grouped in arrays allowing high throughput screening.
Claims19
A microphysiological system having disposed within it a self-contained photonic integrated circuit sensor chip.
A system for studying an analyte of interest released from cells in a microphysiological system device, said system comprising
- (a) a microphysiological system device having a top and a bottom and having disposed within it a self-contained photonic integrated circuit sensor chip (“chip”) having photonic ring sensors, waveguides, an input grating coupler and an output grating coupler, said chip having a front side and a back side, wherein said front side of said chip is closer to said top of said device than is said back side of said chip, and
- (b) an external apparatus for (i) coupling light from a laser to said input grating coupler of said self-contained photonic integrated circuit sensor chip through the back side of said chip and (ii) coupling light from said output grating coupler of said self-contained photonic integrated circuit sensor chip through the back side of said self-contained photonic integrated circuit sensor chip.
A method for studying an analyte of interest released from cells in a microphysiological system device, said method comprising
- (1) providing (a) a microphysiological system device having a top and a bottom and having disposed within said device a self-contained photonic integrated circuit sensor chip (“chip”), said chip having a front side and a back side, wherein said front side is closer to said top of said device than said back side, and having photonic ring sensors, waveguides, an input grating coupler and an output grating coupler, which photonic ring sensors have been derivatized to detect said analyte of interest, and
- (b) an external apparatus for (i) coupling light from a laser to said input grating coupler of said chip through the said back side of said chip and (ii) coupling light from said output grating coupler of said chip through said back side of said chip,
- (2) growing cells in a fluid in said microphysiological system device, and
- (3) contacting said derivatized photonic ring sensors with said fluid in which said cells have been grown,
- whereby a change in light from said derivatized photonic ring sensors indicates the presence of said analyte of interest.
An array of at least two microphysiological system devices, each having disposed within said them a self-contained photonic integrated circuit sensor chip.
Dependencies are inferred from the claim text.