Engineered biologic living materials and methods to make these via advanced manufacturing

Abstract

The present disclosure provides engineered biologic living materials (EBLMs) and methods of making the same. EBLMs can include thermoplastically-molded silk that includes one or more microorganisms of interest that are biologically alive and active embedded within the silk. The EBLMs expand the universe of living materials and are useful in a variety of fields, from probiotic delivery to soil treatment. The compositions disclosed provide a surprising degree of protection to the microorganisms, allowing them to endure conditions that would otherwise be destructive to the microorganisms, including high temperatures and pressures experienced during thermoplastic molding.

Dependencies are inferred from the claim text.