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US 2026/0308281 A1Published application
Chimeric engulfment receptor molecules and methods of use
AssigneeCero Therapeutics Holdings, Inc.
InventorDaniel Mark COREY
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Abstract
The present disclosure relates to chimeric engulfment receptor molecules, host cells modified to include the phagocytic engulfment molecules, and methods of making and using such receptor molecules and modified cells.
Claims31
A chimeric engulfment receptor (CER) comprising a single chain chimeric protein, the single chain chimeric protein comprising:
- an extracellular domain comprising a Tim4 binding domain that binds to phosphatidylserine (PtdSer);
- an engulfment signaling domain that comprises a TLR2 signaling domain;
- and
- a transmembrane domain positioned between and connecting the extracellular domain and the engulfment signaling domain.
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Dependencies are inferred from the claim text.