Anti-ox40 antibody and uses thereof

An isolated nucleic acid, encoding an isolated anti-OX40 antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof comprises:

• (1) one to three selected from HCDR1, HCDR2 and HCDR3 of a heavy chain variable region (VH), wherein the amino acid sequence of the VH is as set forth in SEQ ID NO:
• 1, 2, 3, 4 or 5;
• and/or
• (2) one to three selected from LCDR1, LCDR2 and LCDR3 of a light chain variable region (VL), wherein the amino acid sequence of the VL is as set forth in SEQ ID NO:
• 6, 7, 8, 9 or 10;
• preferably, wherein the antibody or antigen-binding fragment thereof comprises a heavy variable region (VH) comprising the three heavy chain complementarity determining regions HCDR1, HCDR2 and HCDR3 of the heavy chain variable region (VH) of SEQ ID NO:
• 2 and a light variable region (VL) comprising the three light chain complementarity determining regions LCDR1, LCDR2 and LCDR3 of the variable chain light region (VL) of SEQ ID NO:
• 7,
• wherein, the antibody or antigen-binding fragment thereof does not comprise an Fc region variant which is human IgG1 N297A, and wherein the amino acid residues in the Fc region are numbered in accordance with the EU numbering system.