IL-5RAxCD3E T CELL ENGAGING BISPECIFIC ANTIBODY AND USES THEREOF
AssigneeAjou University Industry-Academic Cooperation Foundation
InventorsYong Sung KIM, Jun-Ho KIM
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Abstract
A T cell engaging bispecific antibody is disclosed. More particularly, disclosed are a bispecific antibody that simultaneously binds to human interleukin-5 (IL-5) receptor alpha subunit (IL-5Rα), which is a receptor of human IL-5, and CD3ε, which is a human T cell marker; a nucleic acid encoding same; a vector containing the nucleic acid; a cell transformed with the vector; a method for producing the bispecific antibody or; a composition containing same for the prevention or treatment of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils; and a composition containing same for the diagnosis of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils.
Claims17
A bispecific antibody or antigen-binding fragment thereof binding to interleukin (IL)-5 receptor a (IL-5Rα) and CD3α,
- the bispecific antibody or antigen-binding fragment thereof comprising:
- an antibody or antigen-binding fragment thereof binding to IL-5Rα;
- and
- an antibody or antigen-binding fragment thereof binding to CD3α.
Dependencies are inferred from the claim text.