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AssigneesShaoxing Institute, Zhejiang University, Edipro Pharmaceutical Technology Inc.
InventorsShixian LIN, Wenlong DING, Yongzhao XIONG, Zhijian YAN, Linzhen HU
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The present application relates to a noncanonical amino acid genetic encoding system, comprising a chimeric alanyl-tRNA synthetase (chAlaRS) or a nucleotide sequence encoding the chimeric alanyl-tRNA synthetase. The chimeric alanyl-tRNA synthetase comprises a tRNA binding domain (TD) and a catalytic domain (CD), wherein the tRNA binding domain (TD) and the catalytic domain (CD) of the chimeric alanyl-tRNA synthetase are derived from different aminoacyl-tRNA synthetases. The non-natural amino acid synthesis system is capable of introducing 2-aminoisobutyric acid (Aib) and analogs thereof at specific sites in proteins or polypeptides.
A noncanonical amino acid genetic encoding system for synthesizing polypeptides comprising noncanonical amino acids (ncAA) comprising a chimeric alanyl-tRNA synthetase (chAlaRS) or a nucleotide sequence encoding the chimeric alanyl-tRNA synthetase,
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