Therapeutic composition
OwnerSara GAMEA, Sherif ELSHARKAWYinventors
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Abstract
This invention relates to compositions comprising keratins, to methods of producing such compositions and to their use in various therapeutic applications, particularly in dentistry and bone repair. In particular, it relates to keratin compositions produced by dissolving keratins in a solvent, casting the resulting solution and allowing it to dry.
Claims54
A method of producing a keratin composition, particularly a keratin membrane, comprising the steps of:
- (a) Providing a keratin solution comprising keratin in a solvent;
- (b) Casting the solution on a substrate;
- and
- (c) Allowing the solution to dry.
A keratin solution comprising at least one keratin in a solvent.
A keratin composition, such as a membrane, comprising a keratin.
A method, solution or composition according to any preceding claim wherein keratin or keratins are wool keratins.
A method, solution or composition according to any preceding claim, wherein when the composition comprises more than one keratin, the lightest keratin present in the solution or composition has a molecular weight that is less than 60% of the molecular weight of the heaviest keratin present in the solution or structure.
A method, solution or composition according to any preceding claim, wherein the keratins are highly negative.
A method, solution or composition according to any preceding claim, wherein at least one, or both, several or all of the keratins are alpha-keratins.
A method, solution or composition according to any preceding claim, wherein at least one, or both, several or all of the keratins are high sulphur keratins.
A method or composition according to any preceding claim, wherein the solution comprises a cross-linker, such as triethylene glycol-dimethacrylate (TEGDMA), hexamethylene diisocyantate (HDI) and/or poly-ethylene glycol dimethacrylate (PEGDMA).
A method or composition according to any preceding claim, wherein the keratins are obtained or obtainable by extracting keratin(s) from animal or human hair, fur, wool, hooves, shells, horns, claws, nails, quills or feathers.
A method of extracting keratin from animal or human tissue, such as hair, fur, wool, hooves, shells, horns, claws, nails, quills or feathers, particularly wool comprising the steps of:
- (a) Mixing the tissue with an extraction solution;
- (b) Heating the mixture;
- (c) Separating a keratin containing supernatant from the remainder of the mixture.
A product or kit comprising (a) a keratin solution or composition and (b) a further mineralisation solution and/or crosslinker.
Dependencies are inferred from the claim text.