Rhizavidin variants
AssigneeAffinivax, Inc.
InventorsHeidi BURKE, Brian CIESLEWICZ, Teresa BROERING
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Abstract
The present disclosure provides technologies (e.g., compositions, methods, and kits, etc.) for rhizavidin variants. In particular, the disclosure provides a variant rhizavidin polypeptide, comprising a mutation at one or more N-linked glycosylation sites of a wild-type rhizavidin polypeptide, fusion proteins comprising the variant rhizavidin polypeptide, compositions comprising the variant rhizavidin polypeptide or fusion protein and uses in immunization or methods of immunization.
Claims29
A variant rhizavidin polypeptide, comprising a mutation at one or more N-linked glycosylation sites of a wild-type rhizavidin polypeptide, wherein the wild-type rhizavidin polypeptide comprises the amino acid sequence as set forth below:
- FDASNFKDFSSIASASSSWQNQSGSTMIIQVDSFGNVSGQYVNRAQGTGCONSPY PLTGRVNGTFIAFSVGWNNSTENCNSATGWTGYAQVNGNNTEIVTSWNLAYEG GSGPAIEQGQDTFQYVPTTENKSLL (SEQ ID NO:
- 2), wherein the amino acid sequence of SEQ ID NO:
- 2 corresponds to amino acid residues 45-179 of the wild-type rhizavidin polypeptide.
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Dependencies are inferred from the claim text.