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US 2026/0308207 A1Published application
SYNTHETIC mRNA FOR TREATING EBV-ASSOCIATED DISEASES
AssigneeThe Chinese University of Hong Kong
InventorsKwok Wai LO, Tom Pok Man HAU, Man WU, Anna Chi Man TSANG
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Abstract
Provided synthesized mRNAs that can specifically induce the transcription of one or more Epstein-Barr virus (EBV) lytic genes in EBV-infected cells, thus destroying the cells. Also described herein are methods of synthesizing the mRNAs as well as methods of using the mRNAs for the purpose of treating EBV-associated diseases such as EBV-positive cancers.
Claims29
A nucleic acid comprising a polynucleotide sequence encoding a fusion protein comprising (i) at least one nuclear-localization signal (NLS);
- (ii) a transcription activator-like effector (TA LE) targeting Epstein-Barr virus (EBV) BZLF1, BRLF1, or BGLF4 promoter sequence;
- and (iii) a transactivation domain.
Dependencies are inferred from the claim text.