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US 2026/0308198 A1Published application
Neuroactive steroids substituted in position 10 with a cyclic group for use in the treatment of cns disorders
AssigneeSage Therapeutics, Inc.
InventorsMaria Jesus BLANCO-PILLADO, Francesco G. SALITURO, Marshall Lee MORNINGSTAR
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Abstract
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R19, R5, R3a, R6a, R6b, R1, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, R12b, R17b, R15a, R15b, R16a and R16b are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
Claims20
1-83. (canceled)
A process for preparing compound (A10)
- comprising
- reacting compound (A9)
- with bromine to generate compound (A10).
A process for preparing compound (A11)
- comprising
- reacting compound (A10)
- with 1H-pyrazole-4-carbonitrile in the presence of a base to generate compound (A11).
A process for preparing compound (A9)
- comprising
- reacting compound (A8)
- with Dess-Martin periodinane (DMP) to generate compound (A9).
A compound selected from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.