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US 2026/0308169 A1Published application
Compounds Targeting STAT3 for Use in Treating Pancreatic Cancer
AssigneesUniversity of Florida Research Foundation, Inc., Board of Regents, The University of Texas System
InventorsRita Ghosh, Glenn Halff, Kenneth L. Kho, Addanki Pratap Kumar, Danmeng Li, David A. Ostrov, Xiaoyu Yang
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Abstract
Described herein are compounds that bind to the linker domain of STAT3 and have anti-pancreatic cancer activity. Also described are methods for treating pancreatic cancer in a subject by administering a therapeutically effective dose of the compound of formula (I) or (II).
Claims19
A compound having the structure of formula II:
- wherein:
- —R1 is
- —R2 is
- —R3 is
- —R4 is —CH3 or —OH;
- and
- —R5 is —H or
- and
- wherein:
- (a) if —R1 is
- then
- —R2 is
- —R3
- —R4 —OH;
- and/or
- —R5
- (b) if —R2 is
- then
- —R1 is
- —R3 is,
- —R4 —OH;
- and/or
- —R5 is
- (c) if —R3 is
- then
- —R1 is
- —R2 is
- —R4 is —OH;
- and/or
- —R5 is
- (d) if —R4 is —CH3, then
- —R1 is
- —R2 is
- —R3 is
- and/or
- —R5 is
- and
- (e) if —R5 is —H;
- then
- —R1 is
- —R2 is
- —R3 is
- and/or
- —R4 is —OH.
41 more elements
Dependencies are inferred from the claim text.