Deuterated camptothecin compound, and preparation therefor and use thereof

A compound of Formula II, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof:

• wherein R1 is H, halogen, OH, SH, NH2, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy;
• R2 is H, halogen, C1-4 alkyl, or C1-4 alkoxy;
• or R1 and R2 are cyclized to form —O—(CH2)m—O—, wherein m is 1, 2, or 3;
• R3 and R4 are each independently H, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, or C1-4 haloalkoxy;
• or R3 and R4 are cyclized to form —(CH2)k—, wherein k is 1, 2, 3, or 4;
• X is H, OH, HO—CH(R5)—(CH2)p—CO—NH—, or —N(R6)(R7), wherein p is 0, 1, or 2;
• R5 is H, C1-4 alkyl, C1-4 haloalkyl, 3- to 6-membered cycloalkyl, or 3- to 6-membered heterocycloalkyl;
• R6 is H, C1-4 alkyl, or C1-4 haloalkyl;
• R7 is H or R8—S(O)2—;
• R8 is C1-4 alkyl;
• and
• t is 0, 1, 2, 3, 4, or 5;
• and the compound of Formula II excludes any one of the following compounds: