Novel carboxamide derivatives

A compound of formula (I), or a solvate, or a pharmaceutically acceptable salt thereof:

• wherein
• A1 is N or CRa;
• A2 is N or CRb;
• Ra is hydrogen or a halogen;
• Rb is hydrogen or a halogen;
• R1 is selected from hydrogen, cyano, a haloC1-6alkyl, a C1-6alkoxy, a haloC1-6alkoxy, and a halogen;
• R2 and R3 are independently selected from the group consisting of hydrogen, hydroxy, a C1-6alkyl, a C1-6alkoxy, a hydroxyC1-6alkyl, a C3-5cycloalkylC1-6alkoxy, cyano, —OCD3, a cyanoC1-6alkoxy, a haloC1-6alkoxy, and a hydroxy-C2-4alkenyl, or
• R2 and R3 together with the carbon atom they are attached to form a 4-6 membered heterocycloalkyl or a 3-6 membered cycloalkyl optionally substituted with 1 to 4 halogen, or oxo, or
• R3 is hydrogen, and R2 is ═CHCH2OH;
• R4 is hydrogen, a hydroxyC1-6alkyl, or a halogen;
• R5 is hydrogen, or a halogen;
• X is selected from the group consisting of NH, NHCH2, CH2, CH2CH2, CH2CH2CH2, NHCH2CH2CH2, NHCH2CH2, CH═CH, CH2CH2CH(OH), CH2CH(OH), a bond, CHFCH2, and
• and
• R6 is selected from the group consisting of a 3-10 membered cycloalkyl, a 7-11 membered spiro-cycloalkyl, a 7-11 membered oxo-spiro-heterocycloalkyl, an aryl, a heteroaryl, a C1-6alkyl, —C≡CCH3, a 4-10 membered heterocycloalkyl, and a haloC1-6alkyl, wherein the cycloalkyl, the spiro-cycloalkyl, the 7-11 membered oxa-spiro-cycloalkyl, the aryl, the heteroaryl, or the heterocycloalkyl are optionally substituted with one, two, or three substituents independently selected from the group consisting of a halogen, a haloC1-6alkyl, a C1-6alkyl, a C1-6alkoxy, and a haloC1-6alkoxy.