Substituted oxoisoindolinyl piperidine-2,6-dione compounds and aza analogs thereof

A compound of Formula (I):

• or stereoisomers, tautomers, or salts thereof, wherein:
• (i) X is CR2 and Y is CR4;
• (ii) X is CR2 and Y is N;
• (iii) X is N and Y is N;
• R1 is hydrogen or —CH3;
• R2 is hydrogen or —CH3;
• R3 is hydrogen, F, —CH3, —CHF2, or —CH2N(CH3)2;
• R4 is hydrogen;
• wherein:
• (i) R5a, R5b, and R5c are each hydrogen;
• (ii) R5a and R5b are joined together to form-CH2CH2-or —CH2OCH2—, and R5c is hydrogen;
• or
• (iii) R5a and R5c are joined together to form-CH2—, and R5b is hydrogen;
• Ring A is:
• or
• (ii) indazolyl, indolinyl, dihydrobenzofuranyl, dihydrobenzoxazinyl, tetrahydroquinolinyl, tetrahydrobenzazepinyl, or tetrahydrobenzooxazepinyl;
• Ring B is phenyl, isothiazolyl,
• R6a is hydrogen, Cl, or Br;
• R6b is hydrogen, —OH, —OCH3, —OCD3, —OCH2CH3, —OCH(CH3)2, —OCH2CH2OH, —OCH2CH2OCH3, —OCF3, —OCH2CH2F, —OCH2CH2NH2, —OCH2CH2NH(CH3), —OCH2CH2N(CH3)2, —OCH2CH2CH2NH2, —OCH2CH2CH2N(CH3)2, —OCH2CHFCH2NH2, —OCH2CF2CH2NH2, —OCH(CH3) CH2NH2, —OCH2CH(CH(CH3)2) NH2, —OCH2CH(CH3) NH2, —OCH2CH(CH2CH3) NH2, —OCH2CH(CHF2) NH2, —OCH2CH(CF3) NH2, —OCH2CH(CH2CHF2) NH2, —OCH2CH2NHC(O)CH3, —B(OH)2, —CH2CH2N(CH3)2, —NH(CH3), —N(CH3)2, —NH(CH2CH2OH), —NH(CH2CH2NH2), —NH (aminocyclobutyl), —NHC(O)CH3, —NHC(O)CH2OH, —O(cyclopropyl), —O(cyclobutyl), —O(aminocyclopentyl), —O(methylazetidinyl), —O(methyl pyrrolidinyl), —O(fluoroethyl pyrrolidinyl), —O(trifluoroethyl pyrrolidinyl), —O(methyl azaspiro[3.3]heptanyl), —OCH2(aminocyclopropyl), —OCH2(imidazolyl), —OCH2(methyl imidazolyl), —OCH2(isoxazolyl), —OCH2(oxazolyl), —OCH2(methyl pyrrolidinyl), —OCH2CH2(pyrrolidinyl), morpholinyl, oxazolyl, aminopyrrolidinyl, hydroxypyrrolidinyl, or dihydroimidazo[1,5-a]pyrazinyl;
• R6c is hydrogen or F;
• and
• R7 is hydrogen or deuterium.